Hepatitis A: Natural history, immunopathogenesis, and outcome.
作者信息
Phan Charles, Hollinger F Blaine
机构信息
Departments of Medicine, Molecular Virology, and Surgery, Baylor/St. Luke's Liver Center Baylor College of Medicine Houston TX.
出版信息
Clin Liver Dis (Hoboken). 2013 Dec 20;2(6):231-234. doi: 10.1002/cld.253. eCollection 2013 Dec.
Abstract
摘要
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Nature. 2013 Apr 18;496(7445):367-71. doi: 10.1038/nature12029. Epub 2013 Mar 31.
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Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD.甲型肝炎病毒蛋白酶-聚合酶加工中间体 3CD 对 TRIF 的切割导致 TLR3 信号通路的破坏。
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