Department of Colorectal Surgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, 312000, Zhejiang, People's Republic of China.
Department of Breast and Thyroid Surgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, 312000, Zhejiang, People's Republic of China.
Biotechnol Lett. 2019 Jul;41(6-7):641-650. doi: 10.1007/s10529-019-02675-5. Epub 2019 Apr 16.
Cancer is a complex multifactorial disease for which many promising therapeutic strategies such as immunotherapy are emerging. Malignant cells frequently express aberrant cell surface carbohydrates, which differentiate them from normal "healthy" cells. This characteristic presents a window for the development of synthetic carbohydrate antigen-based cancer vaccines which can be recognized by the immune system and can bring about T cell-dependent immune responses. Antibodies generated against the carbohydrate antigens partake in the inactivation of carbohydrate-decorated cancer cells, by slowing down tumor cell growth and inducing cancer cell apoptosis. Novel synthetic strategies for carbohydrate antigens have led to several synthetic cancer vaccine candidates. In the present review, we describe the latest progress in carbohydrate-based cancer vaccines and their clinical evaluation in various cancers.
癌症是一种复杂的多因素疾病，许多有前途的治疗策略，如免疫疗法，正在出现。恶性细胞经常表达异常的细胞表面碳水化合物，使它们与正常的“健康”细胞区分开来。这一特征为合成基于碳水化合物抗原的癌症疫苗的发展提供了一个窗口，这些疫苗可以被免疫系统识别，并能带来 T 细胞依赖的免疫反应。针对碳水化合物抗原产生的抗体参与了碳水化合物修饰的癌细胞的失活，减缓肿瘤细胞的生长并诱导癌细胞凋亡。碳水化合物抗原的新型合成策略已经产生了几种合成癌症疫苗候选物。在本综述中，我们描述了基于碳水化合物的癌症疫苗的最新进展及其在各种癌症中的临床评估。
