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血清维生素 D3 水平与约旦男孩自闭症之间的关联。

The Association Between Serum Vitamin D3 Levels and Autism Among Jordanian Boys.

机构信息

Department of Physiology and Biochemistry, School of Medicine, The University of Jordan, Amman, 11942, Jordan.

Department of Applied Biological Science, Jordan University of Science and Technology, Irbid, Jordan.

出版信息

J Autism Dev Disord. 2020 Sep;50(9):3149-3154. doi: 10.1007/s10803-019-04017-w.

Abstract

This study assesses the correlation between vitamin-D deficiency and autism spectrum disorder (ASD) in Jordan. We performed a case-controlled cross-sectional analysis to assess vitamin D levels in 83 children with ASD aged less than 8 years old compared to 106 healthy controls. In addition, the association between vitamin D deficiencies and gastrointestinal (GI) complains and electroencephalogram (EEG) abnormalities commonly found in children with ASD was investigated. Vitamin D levels in ASD patients were significantly lower. Also, Vitamin D levels in ASD patients had significant correlation with GI complains, but no correlation between vitamin D levels and Caor EEG abnormalities was detected. These data suggest a possible role for vitamin D deficiency in the pathophysiology of ASD.

摘要

本研究评估了维生素 D 缺乏与约旦自闭症谱系障碍 (ASD) 之间的相关性。我们进行了病例对照的横断面分析,以评估 83 名年龄小于 8 岁的 ASD 儿童与 106 名健康对照儿童的维生素 D 水平。此外,还研究了维生素 D 缺乏与 ASD 儿童常见的胃肠道 (GI) 投诉和脑电图 (EEG) 异常之间的关系。ASD 患者的维生素 D 水平明显较低。此外,ASD 患者的维生素 D 水平与 GI 投诉呈显著相关,但未发现维生素 D 水平与 Caor EEG 异常之间存在相关性。这些数据表明,维生素 D 缺乏可能在 ASD 的病理生理学中起作用。

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