Department of Physiology and Biochemistry, School of Medicine, The University of Jordan, Amman, 11942, Jordan.
Department of Applied Biological Science, Jordan University of Science and Technology, Irbid, Jordan.
J Autism Dev Disord. 2020 Sep;50(9):3149-3154. doi: 10.1007/s10803-019-04017-w.
This study assesses the correlation between vitamin-D deficiency and autism spectrum disorder (ASD) in Jordan. We performed a case-controlled cross-sectional analysis to assess vitamin D levels in 83 children with ASD aged less than 8 years old compared to 106 healthy controls. In addition, the association between vitamin D deficiencies and gastrointestinal (GI) complains and electroencephalogram (EEG) abnormalities commonly found in children with ASD was investigated. Vitamin D levels in ASD patients were significantly lower. Also, Vitamin D levels in ASD patients had significant correlation with GI complains, but no correlation between vitamin D levels and Caor EEG abnormalities was detected. These data suggest a possible role for vitamin D deficiency in the pathophysiology of ASD.
本研究评估了维生素 D 缺乏与约旦自闭症谱系障碍 (ASD) 之间的相关性。我们进行了病例对照的横断面分析,以评估 83 名年龄小于 8 岁的 ASD 儿童与 106 名健康对照儿童的维生素 D 水平。此外,还研究了维生素 D 缺乏与 ASD 儿童常见的胃肠道 (GI) 投诉和脑电图 (EEG) 异常之间的关系。ASD 患者的维生素 D 水平明显较低。此外,ASD 患者的维生素 D 水平与 GI 投诉呈显著相关,但未发现维生素 D 水平与 Caor EEG 异常之间存在相关性。这些数据表明,维生素 D 缺乏可能在 ASD 的病理生理学中起作用。