法罗群岛自闭症青年成年人普通人群中的维生素D
Vitamin d in the general population of young adults with autism in the faroe islands.
作者信息
Kočovská Eva, Andorsdóttir Guðrið, Weihe Pál, Halling Jónrit, Fernell Elisabeth, Stóra Tormóður, Biskupstø Rannvá, Gillberg I Carina, Shea Robyn, Billstedt Eva, Bourgeron Thomas, Minnis Helen, Gillberg Christopher
机构信息
Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Kungsgatan 12, 411 19, Göteborg, Sweden,
出版信息
J Autism Dev Disord. 2014 Dec;44(12):2996-3005. doi: 10.1007/s10803-014-2155-1.
Vitamin D deficiency has been proposed as a possible risk factor for developing autism spectrum disorder (ASD). 25-Hydroxyvitamin D3 (25(OH)D3) levels were examined in a cross-sectional population-based study in the Faroe Islands. The case group consisting of a total population cohort of 40 individuals with ASD (aged 15-24 years) had significantly lower 25(OH)D3 than their 62 typically-developing siblings and their 77 parents, and also significantly lower than 40 healthy age and gender matched comparisons. There was a trend for males having lower 25(OH)D3 than females. Effects of age, month/season of birth, IQ, various subcategories of ASD and Autism Diagnostic Observation Schedule score were also investigated, however, no association was found. The very low 25(OH)D3 in the ASD group suggests some underlying pathogenic mechanism.
维生素D缺乏已被认为是发展为自闭症谱系障碍（ASD）的一个可能风险因素。在法罗群岛进行的一项基于人群的横断面研究中，检测了25-羟基维生素D3（25(OH)D3）水平。病例组由40名患有ASD的个体（年龄在15至24岁之间）组成，其25(OH)D3水平显著低于他们的62名发育正常的兄弟姐妹和77名父母，也显著低于40名年龄和性别匹配的健康对照者。男性的25(OH)D3水平有低于女性的趋势。还研究了年龄、出生月份/季节、智商、ASD的各种亚类别以及自闭症诊断观察量表评分的影响，然而，未发现有相关性。ASD组中极低的25(OH)D3表明存在一些潜在的致病机制。
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