Department of Palliative Care, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Department of Oncology and Radiotherapy, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Eur J Cancer Care (Engl). 2019 Jul;28(4):e13059. doi: 10.1111/ecc.13059. Epub 2019 Apr 16.
The role of selected treatments for brain metastases (BM) is well documented; however, the prevalence of these is not. We report on the patterns of care in the management of BM in a large oncology centre.
We retrospectively audited 236 cases of newly diagnosed BM from January 2016 to December 2017 by looking at 2 years of radiology reports and gathered data on primary site, survival, treatment received, palliative care input and brain metastases-related admissions.
Eighty-two per cent of cases were related to lung, breast and melanoma primaries. Half of patients received a form of treatment with the other half receiving best supportive care. Of these, whole-brain radiotherapy (39%) and stereotactic radiosurgery (40%) were the most common treatment modalities. Most common reasons for admissions were headaches, seizures, weakness and confusion.
This is the first study in the UK that gives an in-depth overview of the real-world management of brain metastases. We have demonstrated the prevalence of treatment across the spectrum of brain metastases patients. Radiotherapy is the mainstay of treatment in nearly 80% of cases; however, care needs to be taken in ensuring that SRS is offered to those who are suitable.
已有大量文献记载了各种针对脑转移瘤（BM）的治疗方法，然而，这些治疗方法的应用率尚不清楚。我们报告了在一个大型肿瘤中心对脑转移瘤的管理模式。
我们通过查阅 2 年的放射学报告，对 2016 年 1 月至 2017 年 12 月期间新诊断为脑转移瘤的 236 例病例进行了回顾性审核，并收集了原发部位、生存情况、接受的治疗、姑息治疗的投入以及与脑转移瘤相关的入院等数据。
82%的病例与肺癌、乳腺癌和黑色素瘤有关。一半的患者接受了某种形式的治疗，另一半患者接受了最佳支持性护理。其中，全脑放疗（39%）和立体定向放射外科（40%）是最常见的治疗方式。最常见的入院原因是头痛、癫痫、虚弱和意识混乱。
这是英国第一项深入概述脑转移瘤实际管理情况的研究。我们已经证明了在脑转移瘤患者中各种治疗方法的应用率。放射治疗在近 80%的病例中是主要的治疗方法；然而，需要注意的是，要确保向合适的患者提供 SRS 治疗。
