Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering , Kansai University , Suita , Osaka 564-8680 , Japan.
Org Lett. 2019 May 3;21(9):3299-3303. doi: 10.1021/acs.orglett.9b01025. Epub 2019 Apr 17.
IrCl(cod)]/dppe-catalyzed α-methylation of aryl esters using methanol as the C1 source was developed. This methylation process is useful in several fields including organic chemistry, biochemistry, and medicinal chemistry. Readily available methanol as methylation reagent was successfully adapted. The reaction processed high atom economy and efficient. By applying the reaction system, the synthesis method of naproxen was provided.
IrCl(cod)]/dppe 催化的以甲醇作为 C1 源的芳基酯的 α-甲基化反应被开发出来。该甲基化过程在有机化学、生物化学和药物化学等多个领域都具有重要应用。本研究成功地利用了易得的甲醇作为甲基化试剂。该反应具有高原子经济性和高效性。通过应用该反应体系，提供了萘普生的合成方法。
