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经导管二尖瓣置换术的作用是什么?

[What role for transcatheter mitral valve replacement?].

作者信息

De Marco Federico, Casenghi Matteo, Garatti Andrea, Guerrini Marco, Tusa Maurizio, Bedogni Francesco

机构信息

Cardiologia Clinica-UTIC ed Interventistica, IRCCS Policlinico San Donato, San Donato Milanese (MI).

Cardiochirurgia, IRCCS Policlinico San Donato, San Donato Milanese (MI).

出版信息

G Ital Cardiol (Rome). 2019 Apr;20(4 Suppl 1):20S-26S. doi: 10.1714/3146.31275.

Abstract

Despite the safety and efficacy of transmitral valve repair techniques, transcatheter mitral valve replacement (TMVR) has emerged as a potential treatment option for patients with severe mitral regurgitation at high or prohibitive surgical risk. To date, over 250 high-risk patients with severe mitral regurgitation have been treated with 10 different TMVR devices, demonstrating the feasibility of this technique. Parallel to the potential advantages of this procedure (reproducible mitral regurgitation reduction, possibility of targeting all potential anatomic variations), many challenges has emerged during the design and implantation phases. Further larger studies with longer follow-up are needed to evaluate safety and efficacy of TMVR.

摘要

尽管经二尖瓣修复技术具有安全性和有效性,但经导管二尖瓣置换术(TMVR)已成为手术风险高或手术禁忌的严重二尖瓣反流患者的一种潜在治疗选择。迄今为止,已有超过250例严重二尖瓣反流的高危患者接受了10种不同的TMVR装置治疗,证明了该技术的可行性。与该手术的潜在优势(可重复性减少二尖瓣反流、针对所有潜在解剖变异的可能性)并行的是,在设计和植入阶段出现了许多挑战。需要进一步开展更大规模、随访时间更长的研究来评估TMVR的安全性和有效性。

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