磷抗原识别的 X 射线视觉。
An X-ray Vision for Phosphoantigen Recognition.
机构信息
Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
CRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France.
出版信息
Immunity. 2019 Apr 16;50(4):1026-1028. doi: 10.1016/j.immuni.2019.03.015.
PMID:30995494
Abstract
Invariant Vγ9Vδ2 T cells respond to "phosphoantigen" metabolites through binding to the B30.2 domain of butyrophilin BTN3A. Yang et al. (2019) use molecular dynamic simulations based on X-ray structures of distinct B30.2 domain dimers to identify the asymmetric dimer as most active, which has implications for the inside-out signaling mechanism.
摘要
不变 Vγ9Vδ2 T 细胞通过与丁酰膦酸结合蛋白 BTN3A 的 B30.2 结构域结合来响应“磷酸抗原”代谢物。Yang 等人。（2019 年）使用基于不同 B30.2 结构域二聚体的 X 射线结构的分子动力学模拟来鉴定最活跃的不对称二聚体，这对内部信号转导机制有影响。
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