MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK; Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK.
MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK; Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK.
Immunity. 2019 Apr 16;50(4):1029-1031. doi: 10.1016/j.immuni.2019.03.019.
Genome-wide association studies in ulcerative colitis point to a role for FcγRIIA, a receptor for IgG. Castro-Dopico et al. (2019) find a profound induction of anti-commensal IgG in the colonic mucosa of UC patients and outline a pathway whereby FcγR activation by IgG triggers IL-1β production, type 17 immunity, and the exacerbation of inflammation.
全基因组关联研究在溃疡性结肠炎中指出了 FcγRIIA 的作用，FcγRIIA 是 IgG 的受体。Castro-Dopico 等人（2019 年）发现 UC 患者结肠黏膜中存在严重的抗共生 IgG 诱导，并概述了一种途径，即 IgG 激活 FcγR 触发 IL-1β 产生、17 型免疫和炎症加剧。
