McCollin Abeo, Swann Rebecca L, Summers Michael C, Handyside Alan H, Ottolini Christian S
London Women's Clinic, One St Thomas Street, London, SE1 9RY, UK.
The Evewell, 61 Harley Street, London, W1G 8QU, UK.
Eur J Med Genet. 2020 Feb;63(2):103651. doi: 10.1016/j.ejmg.2019.04.008. Epub 2019 Apr 14.
Despite improvements in culture conditions and laboratory techniques still only about 50% of human embryos reach the blastocyst stage of development in vitro. While many factors influence embryo development, aberrant cleavage divisions have only recently been shown to directly affect the genome in individual cells of human embryos resulting in chromosome loss, mosaicism and cell arrest. In this article we review the current literature in the area of aberrant cleavage in human embryos and its effect on blastocyst development. Further to this, we propose a series of common abnormal cleavage events, with particular attention to timing and frequency, and illustrate how these might influence a number of different embryo fates.
尽管培养条件和实验室技术有所改进，但在体外培养时，仍只有约50%的人类胚胎能发育到囊胚阶段。虽然许多因素会影响胚胎发育，但异常的卵裂分裂直到最近才被证明会直接影响人类胚胎单个细胞中的基因组，导致染色体丢失、嵌合体和细胞停滞。在本文中，我们综述了人类胚胎异常卵裂及其对囊胚发育影响领域的当前文献。除此之外，我们提出了一系列常见的异常卵裂事件，特别关注其时间和频率，并说明这些事件可能如何影响多种不同的胚胎命运。
