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A hidden footprint: embryological origins of age related macular degeneration.

作者信息

Jeffery Glen, Sivaprasad Sobha

机构信息

Institute of Ophthalmology, University College London, London, UK.

出版信息

Eye (Lond). 2019 Nov;33(11):1675-1676. doi: 10.1038/s41433-019-0444-9. Epub 2019 Apr 17.

DOI:10.1038/s41433-019-0444-9
PMID:30996337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7002369/
Abstract
摘要

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A hidden footprint: embryological origins of age related macular degeneration.一个隐藏的根源：年龄相关性黄斑变性的胚胎学起源
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2
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本文引用的文献

1
Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration.补体因子 H 调控视网膜发育，其缺失可能为年龄相关性黄斑变性奠定基础。
Sci Rep. 2019 Jan 31;9(1):1082. doi: 10.1038/s41598-018-37673-6.
2
Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology.饲养在清洁屏障环境中的老年补体因子H基因敲除小鼠的视网膜病变有所减轻。
Exp Eye Res. 2016 Aug;149:116-125. doi: 10.1016/j.exer.2016.07.002. Epub 2016 Jul 7.
3
Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light.在视网膜变性的补体因子H小鼠模型中，线粒体衰退先于表型发展，但可通过近红外光纠正。
Neurobiol Aging. 2015 Oct;36(10):2869-76. doi: 10.1016/j.neurobiolaging.2015.06.010. Epub 2015 Jun 15.
4
Alterations of choroidal blood flow regulation in young healthy subjects with complement factor H polymorphism.年轻健康的补体因子 H 多态性受试者脉络膜血流调节的改变。
PLoS One. 2013 Apr 15;8(4):e60424. doi: 10.1371/journal.pone.0060424. Print 2013.
5
Elevated membrane attack complex in human choroid with high risk complement factor H genotypes.人脉络膜中膜攻击复合物升高与高风险补体因子 H 基因型有关。
Exp Eye Res. 2011 Oct;93(4):565-7. doi: 10.1016/j.exer.2011.06.015. Epub 2011 Jun 26.
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The classical complement cascade mediates CNS synapse elimination.经典补体级联反应介导中枢神经系统突触消除。
Cell. 2007 Dec 14;131(6):1164-78. doi: 10.1016/j.cell.2007.10.036.
7
Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.老年小鼠中的补体因子H缺乏会导致视网膜异常和视觉功能障碍。
Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16651-6. doi: 10.1073/pnas.0705079104. Epub 2007 Oct 5.
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Regulation of choroid development by the retinal pigment epithelium.视网膜色素上皮对脉络膜发育的调控。
Mol Vis. 2001 Dec 2;7:277-82.
9
Regulating proliferation during retinal development.视网膜发育过程中的增殖调控。
Nat Rev Neurosci. 2001 May;2(5):333-42. doi: 10.1038/35072555.
10
The retinal pigment epithelium as a developmental regulator of the neural retina.
Eye (Lond). 1998;12 ( Pt 3b):499-503. doi: 10.1038/eye.1998.137.