用于小鼠胚胎细胞系的促细胞分裂剂。

Mitogens for murine embryo cell lines.

作者信息

Herschman H R, Passovoy D S, Pruss R M, Aharonov A

出版信息

J Supramol Struct. 1978;8(3):263-8. doi: 10.1002/jss.400080305.

Abstract

The growth-promoting activities of fetal bovine serum, cortisol, phorbol myristate acetate, prostaglandin F2alpha, insulin, epidermal growth factor, and fibroblast growth factor were evaluated on four murine embryo cell lines (Swiss 3T3, Balb 3T3, M2, and C3H10T 1/2). Each cell has an unique response spectrum to this collection of reported mitogens. Phorbol myristate acetate and prostaglandin F2alpha were active only on selected cell lines; cortisol was inactive on all four lines. Serum, epidermal growth factor, and fibroblast growth factor were able to stimulate cell division in all four lines, albeit to varying degrees for the different target cells.

摘要

对四种小鼠胚胎细胞系（瑞士3T3、Balb 3T3、M2和C3H10T 1/2）评估了胎牛血清、皮质醇、佛波酯、前列腺素F2α、胰岛素、表皮生长因子和成纤维细胞生长因子的促生长活性。每种细胞对这组已报道的促细胞分裂剂都有独特的反应谱。佛波酯和前列腺素F2α仅对选定的细胞系有活性；皮质醇对所有四种细胞系均无活性。血清、表皮生长因子和成纤维细胞生长因子能够刺激所有四种细胞系的细胞分裂，尽管对不同靶细胞的刺激程度不同。