Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, Bari, Italy.
Department of Biomedical Science and Human Oncology, Obstetrics and Gynecology Unit, University of Bari, Bari, Italy.
Ann Hematol. 2019 Aug;98(8):1947-1952. doi: 10.1007/s00277-019-03684-0. Epub 2019 Apr 17.
Thanks to the increased number of young survivors of Hodgkin's lymphoma (HL), management of the pregnancies of women who have a history of exposure to chemotherapies and radiation therapy is becoming increasingly common. Many patients and clinicians are worried that pregnancy after the diagnosis of HL may increase the risk of relapse, despite a lack of empirical evidence to support such concerns. In the present study, we included 89 women diagnosed with HL between 2006 and 2015 under the age of 50 years, who were in complete remission and alive without relapse > 1 year after treatment. We determined the pregnancy rate, time to pregnancy, and the disease-free survival. We found no evidence of significant impairment of the fertility of female HL long-term survivors and no evidence that a pregnancy increases the relapse rate among women in remission from HL. Survivors of HL need to consider a range of factors when deciding on future reproduction.
由于霍奇金淋巴瘤 (HL) 的年轻幸存者数量增加，管理曾接受化疗和放疗的女性的妊娠变得越来越常见。尽管缺乏经验证据支持这种担忧，但许多患者和临床医生担心 HL 诊断后怀孕可能会增加复发的风险。在本研究中，我们纳入了 89 名 2006 年至 2015 年间诊断为 HL 的女性，年龄均小于 50 岁，她们在治疗后完全缓解且无复发超过 1 年。我们确定了妊娠率、妊娠时间和无病生存率。我们没有发现 HL 长期幸存者的生育能力显著受损的证据，也没有发现怀孕会增加 HL 缓解期妇女复发率的证据。HL 的幸存者在决定未来生育时需要考虑一系列因素。
