异丙肾上腺素处理的大鼠心脏和脾脏中N1-乙酰亚精胺的积累。
Accumulation of N1-acetylspermidine in heart and spleen of isoprenaline-treated rats.
作者信息
Stefanelli C, Carati D, Rossoni C, Flamigni F, Caldarera C M
出版信息
Biochem J. 1986 Aug 1;237(3):931-4. doi: 10.1042/bj2370931.
Abstract
N1-Acetylspermidine is not detectable in rat heart, but its content greatly increases after a single injection of isoprenaline (10 mg/kg), reaching a concentration of about 10 nmol/g of tissue 4 h after the treatment. Part of the accumulated N1-acetylspermidine was split to putrescine. Isoprenaline also caused an increase of N1-acetylspermidine in the spleen, where its concentration increased 3.5-fold 6 h after the catecholamine. The accumulation of N1-acetylspermidine was dependent on the dose of isoprenaline in both the heart and the spleen, and was strongly inhibited by beta-antagonists and inhibitors of protein synthesis.
摘要
在大鼠心脏中检测不到N1-乙酰亚精胺，但单次注射异丙肾上腺素（10mg/kg）后其含量大幅增加，处理后4小时组织浓度达到约10nmol/g。部分积累的N1-乙酰亚精胺分解为腐胺。异丙肾上腺素还导致脾脏中N1-乙酰亚精胺增加，儿茶酚胺注射6小时后其浓度增加3.5倍。心脏和脾脏中N1-乙酰亚精胺的积累均取决于异丙肾上腺素的剂量，并受到β-拮抗剂和蛋白质合成抑制剂的强烈抑制。
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本文引用的文献
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