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难以将后部皮质萎缩的病例与视觉的心因性障碍区分开来。

Difficulty differentiating a case of posterior cortical atrophy from a psychogenic disturbance of vision.

机构信息

Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.

Department of Psychiatry, Juntendo University Shizuoka Hospital, Izunokuni, Japan.

出版信息

Psychogeriatrics. 2020 Jan;20(1):118-123. doi: 10.1111/psyg.12455. Epub 2019 Apr 17.

DOI:10.1111/psyg.12455
PMID:30997705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7004105/
Abstract

Differentiating posterior cortical atrophy (PCA) from other diseases can be difficult and time-consuming, and there is a particularly high possibility of misdiagnosis when psychiatrists diagnose complaints related to visual perception. Here, a case of PCA involving prominent visual perceptual disorders is reported; PCA was difficult to distinguish from psychogenic disturbance of vision in this case. For a year, a 59-year-old woman had had visual perceptual disorders, including a distorted view and prosopagnosia. She underwent examinations at multiple clinical departments at several medical institutions before receiving a definitive diagnosis of PCA. This PCA diagnosis was based on clinical symptoms, including Gerstmann syndrome, Bálint's syndrome, and transcortical sensory aphasia, and hypoperfusion in the occipital lobe observed on single-photon emission computed tomography. This case was initially misdiagnosed as a psychogenic disease partly because characteristic clinical manifestations of PCA include visual agnosia with a disjunctive component. This patient displayed a disordered perception of stationary objects but an intact perception of moving objects. For example, she had to grope her way through a room at home, but she could visit a familiar hair salon on foot without hindrance. Behaviours like claiming to be blind while inexplicably moving without colliding with surrounding objects may lead to the misdiagnosis of PCA as a psychogenic or dissociative disorder involving histrionic or neurologically irrational symptoms with an expectation of sympathy or personal gain. It is critical to make every effort to exclude organic diseases, even in cases provisionally diagnosed as psychogenic disease. Despite its low prevalence, PCA should be considered a syndrome caused by Alzheimer's disease, dementia with Lewy bodies, or other dementias.

摘要

鉴别后部皮质萎缩症(PCA)与其他疾病可能具有挑战性且耗时,当精神科医生诊断与视觉感知相关的主诉时,误诊的可能性特别高。本文报告了一例涉及明显视觉感知障碍的 PCA 病例;在这种情况下,PCA 很难与精神性视觉障碍相区分。一位 59 岁女性,持续 1 年出现视觉感知障碍,包括视物变形和面容失认。她在多家医疗机构的多个临床科室接受了检查,最终才确诊为 PCA。该 PCA 的诊断基于临床症状,包括格斯特曼综合征、巴宾斯基综合征和皮质性感觉性失语,以及单光子发射计算机断层扫描显示的枕叶灌注不足。该病例最初被误诊为精神性疾病,部分原因是 PCA 的特征性临床表现包括具有离散成分的视觉失认。该患者对静止物体的感知出现障碍,但对移动物体的感知正常。例如,她在家中不得不摸索着穿过房间,但可以步行无障碍地前往熟悉的发廊。患者表现出声称失明而又不可思议地行走且不与周围物体碰撞的行为,可能导致 PCA 被误诊为涉及癔症或神经病性不理智症状的精神性或分离性障碍,具有寻求同情或个人获益的期望。即使暂时诊断为精神性疾病,也应尽一切努力排除器质性疾病,这一点至关重要。尽管 PCA 的患病率较低,但仍应将其视为阿尔茨海默病、路易体痴呆或其他痴呆引起的综合征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75eb/7004105/096202ce0f4f/PSYG-20-118-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75eb/7004105/6a62b2ebf5b2/PSYG-20-118-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75eb/7004105/68c70083c257/PSYG-20-118-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75eb/7004105/e6a1056391c1/PSYG-20-118-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75eb/7004105/096202ce0f4f/PSYG-20-118-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75eb/7004105/6a62b2ebf5b2/PSYG-20-118-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75eb/7004105/68c70083c257/PSYG-20-118-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75eb/7004105/e6a1056391c1/PSYG-20-118-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75eb/7004105/096202ce0f4f/PSYG-20-118-g004.jpg

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本文引用的文献

1
Posterior cortical atrophy: an exemplar for renovating diagnostic formulation in neuropsychiatry.后部皮质萎缩:神经精神病学中重新构建诊断模式的范例。
Compr Psychiatry. 2011 May-Jun;52(3):326-33. doi: 10.1016/j.comppsych.2010.06.013. Epub 2010 Sep 6.
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[Clinical characteristics of posterior cortical atrophy].[后皮质萎缩的临床特征]
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Neurology. 2004 Oct 12;63(7):1168-74. doi: 10.1212/01.wnl.0000140289.18472.15.
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Posterior cortical atrophy.后部皮质萎缩
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