Guaraldi G, Malagoli A, Milic J, Pintassilgo I, Rossi E, Riva N, Franconi I, Santoro A, Sorin P, Streinu-Cercel A, De Rosa M, Mussini C
Giovanni Guaraldi, Universita degli Studi di Modena e Reggio Emilia, Italy,
J Frailty Aging. 2019;8(2):88-92. doi: 10.14283/jfa.2019.6.
Understanding the intersection of HIV, aging and health is crucial due to the increasing number of people aging with HIV.
The objective of the study was to assess the prevalence of, and risk factors for individual comorbidities and multi-morbidity in people living with HIV with similar duration of HIV infection, notwithstanding a 25-year difference at the time of HIV acquisition.
In a cross-sectional multicentre retrospective study, we compared three match-control age groups. The "Young" were selected from Romania and included HIV-positive patients prenatally infected and assessed at the age of 25-30 years. The "Old" and the "Geriatric" were selected from Italy. These respectively included subjects infected with HIV at the age of 25 years and assessed at the age of 50-55 years, and those infected at the age of 50 years and assessed at the age of 75-80 years. Each group was sex and age matched in a 1:5 ratio with controls selected from the CINECA ARNO database from Italy. We described non-infectious comorbidities (NICM), including cardiovascular disease, hypertension, dyslipidaemia, diabetes, chronic kidney disease, and multi-morbidity (MM≥ 3 NICM).
MM prevalence in the "Young" group compared to controls was 6.2% vs 0%, while in the "Geriatric" was "68.2% vs 3.6%. Using "Young" as a reference, in multivariate analyses, predictors for MM were as follows: HIV serostatus (OR=47.75, IQR 14.78-154.25, p<0.01) and "Geriatric" vs "Young" (OR=30.32, IQR 5.89-155.98, p<0.01).
These data suggest that age at acquisition of HIV should be considered as a risk factor for NICM and MM.
鉴于感染艾滋病毒的老年人数量不断增加，了解艾滋病毒、衰老与健康之间的交叉关系至关重要。
本研究的目的是评估在感染艾滋病毒时间相似的人群中，尽管感染艾滋病毒的时间相差25年，但个体合并症和多重合并症的患病率及危险因素。
在一项横断面多中心回顾性研究中，我们比较了三个匹配对照年龄组。“年轻组”从罗马尼亚选取，包括产前感染艾滋病毒并在25至30岁时接受评估的艾滋病毒阳性患者。“老年组”和“高龄组”从意大利选取。这两组分别包括25岁感染艾滋病毒并在50至55岁时接受评估的受试者，以及50岁感染艾滋病毒并在75至80岁时接受评估的受试者。每组与从意大利CINECA ARNO数据库中选取的对照按1:5的比例进行性别和年龄匹配。我们描述了非传染性合并症（NICM），包括心血管疾病、高血压、血脂异常、糖尿病、慢性肾脏病以及多重合并症（MM≥3种NICM）。
与对照组相比，“年轻组”的多重合并症患病率为6.2%，而对照组为0%；“高龄组”的患病率为68.2%，而对照组为3.6%。以“年轻组”为参照，在多变量分析中，多重合并症的预测因素如下：艾滋病毒血清学状态（OR=47.75，IQR 14.78 - 154.25，p<0.01）以及“高龄组”与“年轻组”相比（OR=30.32，IQR 5.89 - 155.98，p<0.01）。
这些数据表明，感染艾滋病毒时的年龄应被视为非传染性合并症和多重合并症的一个危险因素。
