Gillard F, Andris C, Lommers E
Service d'Ophtalmologie, CHU Liège, Belgique.
Service de Neuro-Ophtalmologie, CHU Liège, Belgique.
Rev Med Liege. 2019 Apr;74(4):179-184.
The discovery of autoantibodies targeting aquaporin-4 (AQP4) of astrocytes has improved the understanding and management of Neuromyelitis Optica Syndrome Disorders (NMO-SD), previously considered as a variant of multiple sclerosis. Later, the detection of MOG IgG1 antibodies, directed against an oligodendrocyte myelin glycoprotein, made it possible to distinguish pathologies with different clinical and prognostic particularities, then helping the clinician in his diagnostic and therapeutic approach. This clinical case aims to feature the clinical differences, prognosis and therapeutic solutions of these pathologies.
针对星形胶质细胞水通道蛋白4（AQP4）的自身抗体的发现，提高了对视神经脊髓炎谱系障碍（NMO-SD）的认识和管理，NMO-SD以前被认为是多发性硬化症的一种变体。后来，针对少突胶质细胞髓鞘糖蛋白的MOG IgG1抗体的检测，使得区分具有不同临床和预后特征的疾病成为可能，从而有助于临床医生的诊断和治疗方法。本临床病例旨在突出这些疾病的临床差异、预后和治疗方案。
