Zhou Dian, Cheng Hai, Chen Wei, Li Zhen-Yu, Xu Kai-Lin
Institute of Hematology, Xuzhou Medical University The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.Department of Hematology.The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.
Institute of Hematology, Xuzhou Medical University The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.Department of Hematology.The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Apr;27(2):534-538. doi: 10.19746/j.cnki.issn.1009-2137.2019.02.036.
To explore the role of neutrophil-to-lymphocyte ratio（NLR) in patients with newly diagnosed essential thrombocythemia（ET) and its relationship with thrombotic events.
The clinical and follow-up data of 150 ET patients were retrospectively analyzed. The risk factors of thrombotic events and role of NLR by statistical methods.
Age (P<0.01) and JAK2V617F mutation (P<0.01) were the independent risk factors for thrombotic events at diagnosis; WBC count (P<0.05), NLR (P<0.01), age (P<0.05) and thrombosis history at diagnosis (P<0.05) were independent risk factors for future thrombotic events. The ROC curve showed that NLR for prediction of future thrombotic events was suprior to other risk factors. The Kaplan-Meier analysis showed that the progress-free survival time in thrombotic events patients with higher NLR (median survival 22.3 months, 95% CI:17.8-26.8) was significantly shorter than that of patients with lower NLR (median survival 55.5 months, 95% CI:53.4-57.5) . After follow-up 60 months, the thrombosis progress-free survival in lower NLR patients reached 97.4%, while that in the patients with higher NLR was rate 46.7%.
NLR at diagnosis is a better predictive parameter for future thrombotic events than other clinical parameters in ET patients, but without corralations with thrombosis at diagnosis.
探讨中性粒细胞与淋巴细胞比值（NLR）在新诊断的原发性血小板增多症（ET）患者中的作用及其与血栓形成事件的关系。
回顾性分析150例ET患者的临床及随访资料。采用统计学方法分析血栓形成事件的危险因素及NLR的作用。
年龄（P<0.01）和JAK2V617F突变（P<0.01）是诊断时血栓形成事件的独立危险因素；白细胞计数（P<0.05）、NLR（P<0.01）、年龄（P<0.05）和诊断时的血栓形成病史（P<0.05）是未来血栓形成事件的独立危险因素。ROC曲线显示，NLR预测未来血栓形成事件优于其他危险因素。Kaplan-Meier分析显示，NLR较高的血栓形成事件患者的无进展生存时间（中位生存期22.3个月，95%CI：17.8-26.8）明显短于NLR较低的患者（中位生存期55.5个月，95%CI：53.4-57.5）。随访60个月后，NLR较低患者的血栓形成无进展生存率达到97.4%，而NLR较高患者的这一比率为46.7%。
诊断时的NLR是ET患者未来血栓形成事件比其他临床参数更好的预测指标，但与诊断时的血栓形成无相关性。
