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[急性髓系白血病免疫治疗的最新进展——综述]

[Recent Advances in Immunotherapy for Acute Myeloid Leukemia --Review].

作者信息

Xu Bin, Xiao Yi

机构信息

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China E-mail:

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Apr;27(2):633-636. doi: 10.19746/j.cnki.issn1009-2137.2019.02.053.

Abstract

Currently, the traditional chemotherapeutic drugs for acute myeloid leukemia (AML) showed significant curative efficacy, including the improving long-term prognosis and the life quality of the patients, however the traditional chemotherapeuatic drugs showed the some limitatious in the aspects of enhancing the complete remission rate of newly diagnosed AML patients, overcoming the relapse after remission,as well as the primary and secondary drug-resstance to chemotherapeutics. In order to improve the long-term prognisis of patients, the immuno therapy will the best choice for these patients. This review sammarizes the main current advance of immunotherapy of AML at home and abroad, such as antibody-drug conjugate(ADC), bispecific T cell engager (BiTE), chimeric type of antigen receptor T cell (CAR-T) therapy, checkpoint inhibitors; dendritic cell vaccination and peptide vaccines; natural killer cell (NK) therapy and so on.

摘要

目前,用于急性髓系白血病(AML)的传统化疗药物显示出显著的疗效,包括改善患者的长期预后和生活质量,然而,传统化疗药物在提高新诊断AML患者的完全缓解率、克服缓解后复发以及对化疗药物的原发和继发耐药方面存在一些局限性。为了改善患者的长期预后,免疫疗法将是这些患者的最佳选择。本综述总结了目前国内外AML免疫疗法的主要进展,如抗体药物偶联物(ADC)、双特异性T细胞衔接器(BiTE)、嵌合抗原受体T细胞(CAR-T)疗法、检查点抑制剂;树突状细胞疫苗接种和肽疫苗;自然杀伤细胞(NK)疗法等。

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