侧支门静脉对小鼠血吸虫病抵抗力的重要性。
The importance of collateral portal veins for resistance to schistosomiasis in mice.
作者信息
Medeiros M V, Andrade Z A
出版信息
Braz J Med Biol Res. 1986;19(1):85-8.
Mice with portal hypertension and collateral circulation caused by partial portal vein ligation yielded fewer worms than intact or sham-operated controls when infected with 50 Schistosoma mansoni cercariae for 8 weeks. The collateral circulation probably diverted arriving immature worms back to the general circulation where they died as the result of being out of their natural habitat rather than from immune killing. The present data strongly support the concept that a leaky portal system is the main factor in resistance to reinfection in murine schistosomiasis.
通过部分门静脉结扎造成门静脉高压和侧支循环的小鼠，在感染50只曼氏血吸虫尾蚴8周后，产生的虫体比完整或假手术对照组少。侧支循环可能使到达的未成熟虫体回流到体循环中，在体循环中，它们因脱离自然栖息地而死亡，而非因免疫杀伤。目前的数据有力地支持了这样一种观念，即渗漏的门静脉系统是小鼠血吸虫病抵抗再感染的主要因素。
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