O'Donnell B, Puri P
Br Med J (Clin Res Ed). 1986 Nov 29;293(6559):1404-6. doi: 10.1136/bmj.293.6559.1404.
Sixty one patients with primary vesicoureteric reflux were treated by endoscopic injection of Mentor Polytef paste. Seventy six of the 94 treated ureters showed complete disappearance of vesicoureteric reflux after one injection. Eight refluxing ureters required a second injection, one required a third, and one a fourth. Six ureters showed improvement in the grade of reflux after the first injection. Two ureters did not show any change in the grade of reflux after endoscopic injection. The amount of paste injected to correct reflux in the 94 ureters varied from 0.1 to 1.0 ml (mean 0.33 ml). Patients were followed up for three to 25 months (mean 13.4 months). Follow up micturating cystograms in the 94 ureters showed absence of reflux in 83. Eleven ureters showed recurrence of reflux. Recurrence of reflux was attributed to early technical difficulties and to insufficient amounts of polytef paste used in some cases. Follow up urograms did not show evidence of ureteric obstruction in the treated ureters. Endoscopic injection of polytef paste is a safe, simple, and effective procedure for primary vesicoureteric reflux and averts the need for open operation.
61例原发性膀胱输尿管反流患者接受了内镜下注射美敦力聚四氟乙烯糊剂治疗。94条接受治疗的输尿管中，76条在一次注射后膀胱输尿管反流完全消失。8条反流输尿管需要第二次注射，1条需要第三次注射，1条需要第四次注射。6条输尿管在第一次注射后反流程度有所改善。2条输尿管在内镜注射后反流程度未出现任何变化。94条输尿管中用于纠正反流的糊剂用量为0.1至1.0毫升（平均0.33毫升）。患者随访3至25个月（平均13.4个月）。94条输尿管的随访排尿性膀胱造影显示83条无反流。11条输尿管出现反流复发。反流复发归因于早期技术困难以及部分病例中聚四氟乙烯糊剂用量不足。随访尿路造影未显示治疗的输尿管存在输尿管梗阻迹象。内镜下注射聚四氟乙烯糊剂是治疗原发性膀胱输尿管反流的一种安全、简单且有效的方法，避免了开放手术的需要。
