Department of Neurology, Charité-Universitätsmedizin, Charitéplatz 1, 10117, Berlin, Germany.
Department of Neurology, Charité-Universitätsmedizin, Charitéplatz 1, 10117, Berlin, Germany.
Behav Brain Res. 2019 Sep 2;369:111915. doi: 10.1016/j.bbr.2019.111915. Epub 2019 Apr 16.
The neurodegenerative disorder Parkinson's disease affects motor abilities as well as cognition. The gold standard therapy is L-Dopa, which mainly restores motor skills. Therefore, we require additional interventions to sustain cognitive functions in Parkinson's disease. The lifestyle intervention "physical activity" improves adult hippocampal neurogenesis and memory but so far, its impact has not been investigated in rodent models for Parkinson's disease previously treated with the standard therapy. We hereby asked whether physical activity serves as a pro-neurogenic and -cognitive stimulus in dopamine-depleted mice previously treated with L-Dopa. Therefore, we injected dopamine-depleted mice with L-Dopa/Benserazide followed either by exercise or by a sedentary lifestyle. We analysed adult hippocampal neurogenesis histologically and assessed spatial memory in the Morris water maze. Furthermore, we investigated the hippocampal and striatal monoaminergic cross-talk. Physical activity prevented memory decline and was linked to a slower dopamine turnover but did not enhance neurogenesis in dopamine-depleted mice previously treated with L-Dopa. In conclusion, physical activity did not develop its full pro-neurogenic potential in mice previously treated with L-Dopa but sustained spatial cognition in Parkinson's disease.
神经退行性疾病帕金森病不仅影响运动能力，还影响认知能力。左旋多巴是金标准治疗药物，主要恢复运动技能。因此，我们需要额外的干预措施来维持帕金森病患者的认知功能。生活方式干预“体育活动”可以改善成年海马神经发生和记忆力，但迄今为止，它在以前接受过标准治疗的帕金森病啮齿动物模型中的影响尚未得到研究。我们在此询问，体育活动是否可以作为以前接受过左旋多巴治疗的多巴胺耗竭小鼠的促神经发生和认知刺激。因此，我们给多巴胺耗竭的小鼠注射左旋多巴/苯乙嗪，然后让它们运动或保持久坐不动的生活方式。我们从组织学上分析成年海马神经发生，并在 Morris 水迷宫中评估空间记忆。此外，我们还研究了海马和纹状体单胺能的串扰。体育活动可以预防记忆减退，并与较慢的多巴胺周转率有关，但不能增强以前接受过左旋多巴治疗的多巴胺耗竭小鼠的神经发生。总之，体育活动在以前接受过左旋多巴治疗的小鼠中并没有发挥其全部的促神经发生潜力，但在帕金森病中维持了空间认知。
