Duncan A M, Partington M W, Soudek D
Cancer Genet Cytogenet. 1987 Mar;25(1):169-74. doi: 10.1016/0165-4608(87)90173-7.
In situ hybridization with a c-sis probe was performed on peripheral lymphocytes of a man with neurofibromatosis and a ring 22 chromosome. Hybridization was observed on both the normal #22 and the ring 22, indicating that the patient is not constitutionally hemizygous for c-sis. The implications of a ring 22 constitution and the neurofibromatosis phenotype are discussed.
用c-sis探针原位杂交检测一名患有神经纤维瘤病并带有22号环状染色体的男性外周血淋巴细胞。在正常的22号染色体和22号环状染色体上均观察到杂交信号，表明该患者并非c-sis基因的先天性半合子。本文讨论了22号环状染色体构成及神经纤维瘤病表型的意义。
