基于焦虑特质的Wistar大鼠分类：一项使用因子和聚类方法的研究
Categories of Wistar Rats Based on Anxiety Traits: A Study Using Factor and Cluster Method.
作者信息
Radhakrishnan Arathi, Gulia Kamalesh K
机构信息
Division of Sleep Research, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
出版信息
Ann Neurosci. 2018 Dec;25(4):234-240. doi: 10.1159/000492268. Epub 2018 Aug 15.
BACKGROUND
Outcomes of neurobehavioral studies are invariably affected by the variations in the anxiety traits of animals in the same species. Identifying those traits and categorizing them accordingly would improve the reproducibility of results, and reduce the variation in the results from different laboratories.
PURPOSE
The present study was done to identify the possible groups among the normal population of outbred adult male Wistar rats.
METHODS
Anxiety traits were measured in elevated plus maze (EPM) test and open field test (OFT). The various anxiety responses from these tests were subjected to exploratory factor and hierarchical cluster analyses. Different clusters thus derived were compared with each other.
RESULTS AND CONCLUSION
In exploratory factorial analysis, 2 components, that is, anxiety and activity were derived from the EPM and OFT parameters. Cluster analysis of EPM parameters classified the rats into 3 groups "high anxiety and low activity", "medium anxiety and high activity", and "low anxiety and medium activity". Whereas, cluster analysis on OFT parameters identified one more group namely "low anxiety and high activity". The rats which came under the clusters formed from the EPM and OFT parameters were not identical. Moreover, EPM and OFT may be measuring different aspects of anxiety.
背景
神经行为学研究的结果总是受到同一物种动物焦虑特质差异的影响。识别这些特质并进行相应分类将提高结果的可重复性，并减少不同实验室结果的差异。
目的
本研究旨在识别远交成年雄性Wistar大鼠正常群体中可能存在的分组。
方法
在高架十字迷宫（EPM）试验和旷场试验（OFT）中测量焦虑特质。对这些试验的各种焦虑反应进行探索性因子分析和层次聚类分析。对由此得出的不同聚类进行相互比较。
结果与结论
在探索性因子分析中，从EPM和OFT参数中得出了2个成分，即焦虑和活动。对EPM参数进行聚类分析，将大鼠分为“高焦虑和低活动”、“中等焦虑和高活动”以及“低焦虑和中等活动”3组。而对OFT参数进行聚类分析又识别出了另外一组，即“低焦虑和高活动”组。由EPM和OFT参数形成的聚类中的大鼠并不相同。此外，EPM和OFT可能测量的是焦虑的不同方面。
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