Immanuel Kant Baltic Federal University, Kaliningrad, Russia.
Pavlov Institute of Physiology, Russian Academy of Sciences, Saint- Petersburg, Russia.
PLoS One. 2021 Jul 29;16(7):e0255380. doi: 10.1371/journal.pone.0255380. eCollection 2021.
Patients with post-stress pathologies display the signs of inflammation in the peripheral blood as well as in the brain. The mechanisms of such post-stress neuroimmune changes, their contribution to the behavior, the relationship of the intensity of inflammation with genetically determined features have not been clarified. The goal of this work was to evaluate the dynamics of post-stress inflammation in the blood and hippocampus of rats which differ in level of excitability of the nervous system. Rats of two strains (high/low excitability threshold) were subjected to stress according to the K. Hecht protocol and their behavior, neutrophil:lymphocyte ratio and the number of Iba+ cells in the hippocampus were analysed 24 hours, 7 and 24 days after stress exposure. Highly excitable animals show an increase in anxiety-like behavior, in the number of neutrophils compared to lymphocytes as well as in the number of Iba1+ cells in CA1, CA3 and DG areas of the hippocampus in response to stress. Thus, hereditary high excitability of the nervous system is a possible risk factor for the development of post-stress pathologies.
应激后病理学患者的外周血和大脑中都显示出炎症迹象。这种应激后神经免疫变化的机制、它们对行为的贡献、炎症强度与遗传决定特征的关系尚不清楚。本工作的目的是评估两种不同神经系统兴奋性水平的大鼠应激后血液和海马体中炎症的动态变化。根据 K. Hecht 方案对大鼠进行应激处理，分析应激暴露后 24 小时、7 天和 24 天的行为、中性粒细胞与淋巴细胞比值以及海马体中 Iba+细胞的数量。高兴奋性动物表现出焦虑样行为增加，与淋巴细胞相比，中性粒细胞数量增加，以及海马体 CA1、CA3 和 DG 区的 Iba1+细胞数量增加。因此，遗传性神经系统高兴奋性可能是应激后病理发生的一个潜在危险因素。
