Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Front Immunol. 2019 Apr 3;10:688. doi: 10.3389/fimmu.2019.00688. eCollection 2019.
In addition to transcription factor binding, the dynamics of DNA modifications (methylation) and chromatin structure are essential contributors to the control of transcription in eukaryotes. Research in the past few years has emphasized the importance of histone H3 methylation at lysine 27 for lineage specific gene repression, demonstrated that deposition of this mark at specific genes is subject to differentiation-induced changes during development, and identified enzymatic activities, methyl transferases and demethylases, that control these changes. The present review discusses the importance of these mechanisms during intrathymic αβ T cell selection and late differentiation.
除了转录因子结合，DNA 修饰（甲基化）和染色质结构的动态变化也是真核生物转录调控的重要因素。过去几年的研究强调了组蛋白 H3 赖氨酸 27 位甲基化对于谱系特异性基因抑制的重要性，表明在发育过程中，该标记在特定基因上的沉积受分化诱导变化的影响，并确定了控制这些变化的酶活性、甲基转移酶和去甲基酶。本综述讨论了这些机制在胸腺内 αβ T 细胞选择和晚期分化过程中的重要性。
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