Wu Chuyan, Jiang Feng, Wei Ke, Lin Feng, Jiang Zhongli
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Neonatal Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Int J Endocrinol. 2019 Mar 13;2019:8405796. doi: 10.1155/2019/8405796. eCollection 2019.
Exercise can reduce androgen and insulin levels in polycystic ovary syndrome (PCOS) patients. Finasteride is also presumed to improve the developing follicle environment. Therefore, the aim of this study was to observe the effects of the combination of exercise and finasteride therapy on hormone levels and ovarian morphology in rats with polycystic ovary syndrome. Forty female rats were randomly divided into five groups ( = 8 each group): the PCOS sedentary group (P-Sed), PCOS exercise group (P-Ex), PCOS finasteride and sedentary group (P-FSed), and PCOS finasteride and exercise group (P-FEx), and healthy, age-matched rats were used as controls (CO). The results indicated that the levels of FINS in the P-FEx group were significantly lower than those in the P-Sed and P-FSed groups, while the ratio of fasting blood glucose (FBG)/fasting serum levels of insulin (FINS) in the P-FEx group was significantly higher than that in the P-Sed and P-FSed groups. Compared to the P-FEx group, serum levels of TT (total testosterone) in the P-Sed and P-FSed groups were significantly increased. The thickness of the follicular membrane and the number of atresia follicles in the P-FEx and CO groups were significantly lower than those in the P-Sed group, but there was no significant difference between the P-Ex and P-Sed groups. These results show that the combined usage of exercise and finasteride does not alter the effects of exercise on increasing insulin sensitivity and reducing androgen levels. There is also a synergistic effect of exercise and finasteride on the morphology of the ovary, including a reduced number of atresia follicles and thickness of the follicular membrane.
运动可降低多囊卵巢综合征（PCOS）患者的雄激素和胰岛素水平。非那雄胺也被认为可改善发育中的卵泡环境。因此，本研究的目的是观察运动与非那雄胺联合治疗对多囊卵巢综合征大鼠激素水平和卵巢形态的影响。40只雌性大鼠随机分为五组（每组 = 8只）：PCOS久坐组（P-Sed）、PCOS运动组（P-Ex）、PCOS非那雄胺与久坐组（P-FSed）、PCOS非那雄胺与运动组（P-FEx），并将健康、年龄匹配的大鼠作为对照组（CO）。结果表明，P-FEx组的空腹胰岛素（FINS）水平显著低于P-Sed组和P-FSed组，而P-FEx组的空腹血糖（FBG）/空腹血清胰岛素（FINS）比值显著高于P-Sed组和P-FSed组。与P-FEx组相比，P-Sed组和P-FSed组的血清总睾酮（TT）水平显著升高。P-FEx组和CO组的卵泡膜厚度和闭锁卵泡数量显著低于P-Sed组，但P-Ex组和P-Sed组之间无显著差异。这些结果表明，运动与非那雄胺联合使用不会改变运动对提高胰岛素敏感性和降低雄激素水平的作用。运动和非那雄胺对卵巢形态也有协同作用，包括减少闭锁卵泡数量和卵泡膜厚度。
