Ranjbar Mohammad-Ali, Ranjbar Zahra, Zahed Maryam, Nikookar Negar
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
J Clin Exp Dent. 2019 Mar 1;11(3):e213-e218. doi: 10.4317/jced.54918. eCollection 2019 Mar.
Ecto-5'-nucleotidase (CD73) plays an important role in the development of several types of cancer; however, its prognostic significance in salivary gland tumors remains unknown. The current study was conducted to investigate the expression of CD73 in such tumors.
In this retrospective study, immunohistochemical expression of CD73 was evaluated in 25 pleomorphic adenomas, 20 mucoepidermoid carcinomas and 20 adenoid cystic carcinomas using the Envision technique. Labeling indices of CD73 expression were calculated and compared between lesions.
Immunohistochemical analysis demonstrated that the CD73 expression was significantly higher in salivary gland tumors than in normal salivary gland tissue (<0.001). CD73 expression was significantly higher in mucoepidermoid carcinoma and adenoid cystic carcinoma compared to pleomorphic adenoma <0.001). In addition, the expression of CD73 was significantly higher in lymph node metastasizing cancers compared to non-metastasizing malignancies (<0.001). In contrast, there was no significant association between CD73 expression and other clinicopathological variables such as age, gender, tumor size and distant metastasis (>0.05).
The findings suggest that CD73 can be an independent and useful biomarker for predicting the clinical behavior of salivary gland tumors. Ecto-5'-nucleotidase, immunohistochemistry, salivary gland tumors.
外切5'-核苷酸酶（CD73）在多种癌症的发展中起重要作用；然而，其在涎腺肿瘤中的预后意义尚不清楚。本研究旨在调查CD73在这类肿瘤中的表达情况。
在这项回顾性研究中，采用Envision技术评估了25例多形性腺瘤、20例黏液表皮样癌和20例腺样囊性癌中CD73的免疫组化表达。计算并比较各病变之间CD73表达的标记指数。
免疫组化分析表明，涎腺肿瘤中CD73的表达明显高于正常涎腺组织（<0.001）。与多形性腺瘤相比，黏液表皮样癌和腺样囊性癌中CD73的表达明显更高（<0.001）。此外，与无转移的恶性肿瘤相比，有淋巴结转移的癌症中CD73的表达明显更高（<0.001）。相比之下，CD73表达与年龄、性别、肿瘤大小和远处转移等其他临床病理变量之间无显著关联（>0.05）。
研究结果表明，CD73可以作为预测涎腺肿瘤临床行为的一个独立且有用的生物标志物。外切5'-核苷酸酶、免疫组化、涎腺肿瘤。
