Jaafari-Ashkavandi Zohreh, Ashraf Mohammad Javad, Nazhvani Ali Dehghani, Azizi Zahra
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Tumour Biol. 2016 Feb;37(2):1863-9. doi: 10.1007/s13277-015-3968-z. Epub 2015 Sep 1.
Caveolin-1, a tyrosine-phosphorylated protein, is supposed to have different regulatory roles as promoter or suppressor in many human cancers. However, no published study concerned its expression in benign and malignant salivary gland tumors. The aim of this study was to evaluate and compare the expression of Cav-1 in the most common benign and malignant salivary gland tumors and evaluate its correlation with proliferation activity. In this cross-sectional retrospective study, immunohistochemical expression of caveolin-1 and Ki67 were evaluated in 49 samples, including 11 normal salivary glands, 15 cases of pleomorphic adenoma (PA), 13 adenoid cystic carcinomas (AdCC), and 10 mucoepidermoid carcinomas (MEC). The expression of Cav-1 was seen in 18 % of normal salivary glands and 85 % of tumors. The immunoreaction in the tumors was significantly higher than normal tissues (P = 0.001), but the difference between benign and malignant tumors was not significant (P = 0.07). Expression of Cav-1 was correlated with Ki67 labeling index in PAs, but not in malignant tumors. Cav-1 expression was not in association with tumor size and stage. Overexpression of Cav-1 was found in salivary gland tumors in comparison with normal tissues, but no significant difference was observed between benign and malignant tumors. Cav-1 was inversely correlated with proliferation in PA. Therefore, this marker may participate in tumorigenesis of salivary gland tumors and may be a potential biomarker for cancer treatments.
小窝蛋白-1是一种酪氨酸磷酸化蛋白，在许多人类癌症中被认为作为促进因子或抑制因子发挥不同的调节作用。然而，尚无已发表的研究关注其在涎腺良恶性肿瘤中的表达情况。本研究旨在评估和比较小窝蛋白-1（Cav-1）在最常见的涎腺良恶性肿瘤中的表达，并评估其与增殖活性的相关性。在这项横断面回顾性研究中，对49个样本进行了小窝蛋白-1和Ki67的免疫组化表达评估，其中包括11个正常涎腺、15例多形性腺瘤（PA）、13例腺样囊性癌（AdCC）和10例黏液表皮样癌（MEC）。在18%的正常涎腺和85%的肿瘤中可见Cav-1表达。肿瘤中的免疫反应显著高于正常组织（P = 0.001），但良性和恶性肿瘤之间的差异不显著（P = 0.07）。Cav-1的表达与PA中的Ki67标记指数相关，但在恶性肿瘤中不相关。Cav-1表达与肿瘤大小和分期无关。与正常组织相比，涎腺肿瘤中发现Cav-1过表达，但良性和恶性肿瘤之间未观察到显著差异。Cav-1与PA中的增殖呈负相关。因此，该标志物可能参与涎腺肿瘤的发生，可能是癌症治疗的潜在生物标志物。
