Sperl Corinna, Gerber Vinzenz, Drießlein David, Klima Andre, Becher Anne M
Swiss Institute of Equine Medicine (ISME), University of Bern, Bern, Switzerland.
Ludwig-Maximilians-Universität München, Statistical Consulting Unit StaBLab, München, Germany.
J Equine Vet Sci. 2019 Apr;75:104-111. doi: 10.1016/j.jevs.2019.01.006. Epub 2019 Jan 30.
Respiratory signs or more specifically severe equine asthma (SEA) is in some studies reported to be associated with decreased strongyle egg shedding. This association can be reproduced in a larger population of unrelated horses. The owners of 209 horses, on seven farms in Bavaria, were interviewed using, an in prior studies validated questionnaire. Horses were categorized into classes of the horse owner assessed respiratory signs index (HOARSI 1-4, unaffected to severely affected). In total, 1,035 fecal samples were analyzed between March 2011 and September 2014 using a modified McMaster procedure resulting in fecal egg counts (FECs). The HOARSI categories were categorized into two groups in two ways: HOARSI 1 versus HOARSI 2, 3, 4 in model A and HOARSI 1 versus HOARSI 3 and 4 in model B, and further variables known to influence strongyle egg shedding, such as age and seasonality, time on pasture, and pasture hygiene were included in a generalized additive mixed model. The mean FECs (35-320 eggs per gram feces) was different between the farms. In the model, the effect of the presence or absence of respiratory signs on the FECs varied in its direction between the farms and was not significant. The effect of the horse itself, the age of the horse, and seasonality was significant (P < .05). These results are in contrast to some prior studies. Future studies should investigate if these differences are caused by genetic effects only present in some respiratory clinical signs and or SEA-affected horses.
在一些研究中，呼吸道症状或更具体地说是严重马哮喘（SEA）被报道与圆线虫虫卵排出减少有关。这种关联在更多无关马匹群体中也能得到重现。对巴伐利亚七个农场的209匹马的主人进行了访谈，使用的是在先前研究中经过验证的问卷。根据马主人评估的呼吸道症状指数（HOARSI 1 - 4，从未受影响到严重受影响）对马匹进行分类。在2011年3月至2014年9月期间，总共使用改良的麦克马斯特程序分析了1035份粪便样本，得出粪便虫卵计数（FECs）。HOARSI类别以两种方式分为两组：在模型A中HOARSI 1与HOARSI 2、3、4对比，在模型B中HOARSI 1与HOARSI 3和4对比，并且将已知会影响圆线虫虫卵排出的其他变量，如年龄、季节性、在牧场的时间以及牧场卫生状况纳入广义相加混合模型。各农场之间的平均FECs（每克粪便35 - 320个虫卵）有所不同。在该模型中，呼吸道症状的有无对FECs的影响在各农场之间方向不同且不显著。马本身、马的年龄以及季节性的影响是显著的（P < .05）。这些结果与一些先前的研究相反。未来的研究应调查这些差异是否仅由某些呼吸道临床症状或受SEA影响的马匹中存在的遗传效应引起。
