Emerg Infect Dis. 2019 May;25(5):875-82. doi: 10.3201/eid2505.181733.
Staphylococcus aureus bacteremia (SAB) is a major cause of illness and death worldwide. We analyzed temporal trends of SAB incidence and death in Denmark during 2008-2015. SAB incidence increased 48%, from 20.76 to 30.37 per 100,000 person-years, during this period (p<0.001). The largest change in incidence was observed for persons >80 years of age: a 90% increase in the SAB rate (p<0.001). After adjusting for demographic changes, annual rates increased 4.0% (95% CI 3.0-5.0) for persons <80 years of age, 8.4% (95% CI 7.0-11.0) for persons 80-89 years of age, and 13.0% (95% CI 9.0-17.5) for persons >90 years of age. The 30-day case-fatality rate remained stable at 24%; crude population death rates increased by 53% during 2008-2015 (p<0.001). Specific causes and mechanisms for this rapid increase in SAB incidence among the elderly population remain to be clarified.
金黄色葡萄球菌菌血症 (SAB) 是全球范围内导致疾病和死亡的主要原因。我们分析了 2008-2015 年期间丹麦 SAB 发病率和死亡率的时间趋势。在此期间，SAB 的发病率增加了 48%，从每 100,000 人年 20.76 例增加到 30.37 例（p<0.001）。发病率最大的变化发生在>80 岁的人群中：SAB 发生率增加了 90%（p<0.001）。在调整人口统计学变化后，<80 岁的人群的年发病率增加了 4.0%（95%CI 3.0-5.0），80-89 岁的人群增加了 8.4%（95%CI 7.0-11.0），>90 岁的人群增加了 13.0%（95%CI 9.0-17.5）。30 天病例死亡率保持稳定，为 24%；2008-2015 年期间，粗人群死亡率增加了 53%（p<0.001）。老年人中 SAB 发病率迅速上升的确切原因和机制仍需阐明。
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