镍催化的极性反转羰基与卤代烃的交叉偶联反应
Nickel-Catalyzed Cross-Coupling of Umpolung Carbonyls and Alkyl Halides.
作者信息
Zhu Dianhu, Lv Leiyang, Qiu Zihang, Li Chao-Jun
机构信息
Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis , McGill University , 801 Sherbrooke St. W. , Montreal , Quebec H3A 0B8 , Canada.
出版信息
J Org Chem. 2019 May 17;84(10):6312-6322. doi: 10.1021/acs.joc.9b00649. Epub 2019 Apr 30.
An effective nickel-catalyzed cross-coupling of Umpolung carbonyls and alkyl halides was developed. Complementary to classical alkylation techniques, this reaction utilizes Umpolung carbonyls as the environmentally benign alkyl nucleophiles, providing an efficient and selective catalytic alternative to the traditional use of highly reactive alkyl organometallic reagents.
开发了一种有效的镍催化的极性翻转羰基与卤代烃的交叉偶联反应。与传统的烷基化技术互补，该反应利用极性翻转羰基作为环境友好的烷基亲核试剂，为传统使用高反应性烷基有机金属试剂提供了一种高效且选择性的催化替代方法。
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