Rytenko A N, Balashov K E, Sergeev A V
Eksp Onkol. 1986;8(6):52-7.
It is shown that the damage action of normal peritoneal macrophages of mice includes inhibition of the proliferating activity of the mastocytoma P-815 cells and their complete destruction accompanied by the breaks of their cytoplasmic membrane. Scanning electron microscopy was used to reveal two types of contacts between peritoneal macrophages and cells P-815; the loss of microvilli and the appearance of blebs on cell surface in the case of adsorption of P-815 cells on macrophages; the contact through long filopodia which are sent forth by macrophages in the case when contacting cells are at some distance from each other.
结果表明,小鼠正常腹腔巨噬细胞的损伤作用包括抑制肥大细胞瘤P - 815细胞的增殖活性并使其完全破坏,同时伴有细胞质膜破裂。采用扫描电子显微镜揭示了腹腔巨噬细胞与P - 815细胞之间的两种接触类型:当P - 815细胞吸附在巨噬细胞上时,细胞表面微绒毛丧失并出现泡状突起;当接触细胞彼此相距一定距离时,巨噬细胞伸出长丝状伪足进行接触。