Otu 淀粉样纤维的优势：提高酶活性和延长寿命。
The Upper Hand of the Otu Amyloid Fibers: Increasing Enzymatic Activity and Prolonging Lifespan.
机构信息
Hubrecht Institute of the Royal Netherlands Academy of Arts and Sciences & University Medical Center Utrecht, Utrecht, the Netherlands; Department of Biomedical Science of Cells and Systems, University Medical Center Groningen, Groningen, the Netherlands.
出版信息
Mol Cell. 2019 Apr 18;74(2):225-226. doi: 10.1016/j.molcel.2019.03.038.
PMID:31002803
Abstract
The formation of amyloid fibers is usually associated with aging and neurodegeneration. In this issue of Molecular Cell, Ji et al. (2019) demonstrate that the deubiquitinase Otu coalesces into amyloid-like fibers to enhance its activity and ensure its optimum biological function.
摘要
淀粉样纤维的形成通常与衰老和神经退行性变有关。在本期《分子细胞》中，Ji 等人（2019 年）证明去泛素化酶 Otu 聚集形成类似淀粉样的纤维，以增强其活性并确保其最佳的生物学功能。
Zotero 插件