Hubrecht Institute of the Royal Netherlands Academy of Arts and Sciences & University Medical Center Utrecht, Utrecht, the Netherlands; Department of Biomedical Science of Cells and Systems, University Medical Center Groningen, Groningen, the Netherlands.
Mol Cell. 2019 Apr 18;74(2):225-226. doi: 10.1016/j.molcel.2019.03.038.
The formation of amyloid fibers is usually associated with aging and neurodegeneration. In this issue of Molecular Cell, Ji et al. (2019) demonstrate that the deubiquitinase Otu coalesces into amyloid-like fibers to enhance its activity and ensure its optimum biological function.
淀粉样纤维的形成通常与衰老和神经退行性变有关。在本期《分子细胞》中，Ji 等人（2019 年）证明去泛素化酶 Otu 聚集形成类似淀粉样的纤维，以增强其活性并确保其最佳的生物学功能。
