合成香豆素-4-酮-噁二唑取代类似物作为有效的 -葡萄糖醛酸苷酶抑制剂。
Synthesis of Chromen-4-One-Oxadiazole Substituted Analogs as Potent -Glucuronidase Inhibitors.
机构信息
Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
Department of Chemistry, Hazara University, Mansehra 21300, Khyber Pakhtunkhwa, Pakistan.
出版信息
Molecules. 2019 Apr 18;24(8):1528. doi: 10.3390/molecules24081528.
Chromen-4-one substituted oxadiazole analogs - have been synthesized, characterized and evaluated for -glucuronidase inhibition. All analogs exhibited a variable degree of -glucuronidase inhibitory activity with IC values ranging in between 0.8 ± 0.1-42.3 ± 0.8 μM when compared with the standard d-saccharic acid 1,4 lactone (IC = 48.1 ± 1.2 μM). Structure activity relationship has been established for all compounds. Molecular docking studies were performed to predict the binding interaction of the compounds with the active site of enzyme.
已合成、表征并评价了色满-4-酮取代的噁二唑类似物的 -葡萄糖醛酸苷酶抑制活性。与标准的 D-葡萄糖二酸 1,4-内酯（IC = 48.1 ± 1.2 μM）相比，所有类似物均表现出不同程度的 -葡萄糖醛酸苷酶抑制活性，IC 值范围在 0.8 ± 0.1-42.3 ± 0.8 μM 之间。对所有化合物都建立了构效关系。进行了分子对接研究，以预测化合物与酶活性部位的结合相互作用。
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