聚乙二醇化多聚脲担载受阻脲键用于药物递送。
PEGylated Polyurea Bearing Hindered Urea Bond for Drug Delivery.
机构信息
Chemical Engineering Institute, Changchun University of Technology, 2055 Yan'an Street, Changchun 130012, China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China.
出版信息
Molecules. 2019 Apr 18;24(8):1538. doi: 10.3390/molecules24081538.
In recent years, polyureas with dynamic hindered urea bonds (HUBs), a class of promising biomedical polymers, have attracted wide attention as a result of their controlled hydrolytic properties. The effect of the chemical structures on the properties of polyureas and their assemblies has rarely been reported. In this study, four kinds of polyureas with different chemical groups have been synthesized, and the polyureas from cyclohexyl diisocyanate and tert-butyl diamine showed the fastest hydrolytic rate. The amphiphilic polyurea composed of hydrophobic cyclohexyl-tert-butyl polyurea and hydrophilic poly(ethylene glycol) (PEG) was synthesized for the controlled delivery of the antitumor drug paclitaxel (PTX). The PTX-loaded PEGylated polyurea micelle more effectively entered into the murine breast cancer 4T1 cells and inhibited the corresponding tumor growth in vitro and in vivo. Therefore, the PEGylated polyurea with adjustable degradation might be a promising polymer matrix for drug delivery.
近年来，具有动态受阻脲键（HUB）的聚脲作为一类有前途的生物医学聚合物，由于其可控的水解性质而受到广泛关注。化学结构对聚脲及其组装体性能的影响很少有报道。在这项研究中，合成了四种具有不同化学基团的聚脲，其中环己基二异氰酸酯和叔丁基二胺的聚脲表现出最快的水解速率。由疏水性环己基叔丁基聚脲和亲水性聚（乙二醇）（PEG）组成的两亲性聚脲被用于控制抗癌药物紫杉醇（PTX）的递送。载紫杉醇的 PEG 化聚脲胶束更有效地进入小鼠乳腺癌 4T1 细胞，并在体外和体内抑制相应的肿瘤生长。因此，具有可调节降解的 PEG 化聚脲可能是一种有前途的药物递送聚合物基质。
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