Fauser J, Zwirner M, Schindler A E
Geburtshilfe Frauenheilkd. 1986 Oct;46(10):735-7. doi: 10.1055/s-2008-1035953.
In 46 patients with the diagnosis of "premature menopause" menstrual history, clinical findings and hormonal quantitations were analysed. This clinical entity was evaluated with regard to a rapid verification of the diagnosis. The age of the investigated women with secondary failure to menstruate varied between 13 to 39 years (mean value 29 years). Menstrual history varied considerably. 20 women complained about menopausal symptoms. 5 women had adnexal operations before. Vaginal hormonal cytology, gestagen test and quantitation of the circulating oestradiol concentrations were of little value for establishing the diagnosis, since many of these women revealed premenopausal oestradiol levels. Quantitation of FSH is decisive for establishing the diagnosis. In women under the age of 40 with FSH values above 1000 ng LER 907/ml or above 40 mIU/ml premature ovarian failure can be assumed; however, in individual cases the "gonadotropin resistant ovary syndrome" must be differentiated.
对46例诊断为“早发性绝经”的患者的月经史、临床表现及激素定量进行了分析。就快速确诊这一临床病症进行了评估。继发闭经的受调查女性年龄在13至39岁之间（平均值为29岁）。月经史差异很大。20名女性主诉有更年期症状。5名女性之前接受过附件手术。阴道激素细胞学检查、孕激素试验及循环雌二醇浓度定量对确诊价值不大，因为这些女性中有许多人的雌二醇水平处于绝经前状态。FSH定量对确诊起决定性作用。40岁以下女性FSH值高于1000 ng LER 907/ml或高于40 mIU/ml时，可推断为卵巢早衰；然而，个别病例必须与“促性腺激素抵抗卵巢综合征”相鉴别。
