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Fixed Duration of Venetoclax-Rituximab in Relapsed/Refractory Chronic Lymphocytic Leukemia Eradicates Minimal Residual Disease and Prolongs Survival: Post-Treatment Follow-Up of the MURANO Phase III Study.维奈托克联合利妥昔单抗治疗复发/难治性慢性淋巴细胞白血病的持续时间：MURANO Ⅲ期研究的治疗后随访结果，可消除微小残留病灶并延长生存。
J Clin Oncol. 2019 Feb 1;37(4):269-277. doi: 10.1200/JCO.18.01580. Epub 2018 Dec 3.
2
Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia.复发性 Gly101Val 突变的获得使慢性淋巴细胞白血病患者对 Venetoclax 产生耐药性。
Cancer Discov. 2019 Mar;9(3):342-353. doi: 10.1158/2159-8290.CD-18-1119. Epub 2018 Dec 4.
3
Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial.维奈托克治疗伴有 17p 缺失的慢性淋巴细胞白血病患者：来自 II 期关键性试验全人群的结果。
J Clin Oncol. 2018 Jul 1;36(19):1973-1980. doi: 10.1200/JCO.2017.76.6840. Epub 2018 May 1.
4
Venetoclax-Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia.维奈托克联合利妥昔单抗治疗复发或难治性慢性淋巴细胞白血病。
N Engl J Med. 2018 Mar 22;378(12):1107-1120. doi: 10.1056/NEJMoa1713976.
5
Potential mechanisms of resistance to venetoclax and strategies to circumvent it.对维奈克拉耐药的潜在机制及克服耐药的策略。
BMC Cancer. 2017 Jun 2;17(1):399. doi: 10.1186/s12885-017-3383-5.
6
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia.在复发的慢性淋巴细胞白血病中使用维奈托克靶向BCL2
N Engl J Med. 2016 Jan 28;374(4):311-22. doi: 10.1056/NEJMoa1513257. Epub 2015 Dec 6.
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Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma.淋巴瘤中 BCL2 家族蛋白获得性突变导致对 BH3 模拟物 ABT-199 的耐药性。
Blood. 2014 Jun 26;123(26):4111-9. doi: 10.1182/blood-2014-03-560284. Epub 2014 Apr 30.
8
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.ABT-199，一种强效和选择性的 BCL-2 抑制剂，在发挥抗肿瘤活性的同时不影响血小板。
Nat Med. 2013 Feb;19(2):202-8. doi: 10.1038/nm.3048. Epub 2013 Jan 6.
9
UCSF Chimera--a visualization system for exploratory research and analysis.加州大学旧金山分校奇美拉——一个用于探索性研究与分析的可视化系统。
J Comput Chem. 2004 Oct;25(13):1605-12. doi: 10.1002/jcc.20084.

Venetoclax resistance and acquired mutations in chronic lymphocytic leukemia.

作者信息

Tausch Eugen, Close William, Dolnik Anna, Bloehdorn Johannes, Chyla Brenda, Bullinger Lars, Döhner Hartmut, Mertens Daniel, Stilgenbauer Stephan

机构信息

Department of Internal Medicine III, Ulm University, Ulm, Germany.

Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine, Berlin, Germany.

出版信息

Haematologica. 2019 Sep;104(9):e434-e437. doi: 10.3324/haematol.2019.222588. Epub 2019 Apr 19.

DOI:10.3324/haematol.2019.222588
PMID:31004028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6717583/
Abstract
摘要