Noker P E, Kalin J R, McCarthy D J, el Dareer S M, Chappel C I
Food Chem Toxicol. 1986 Dec;24(12):1287-93. doi: 10.1016/0278-6915(86)90060-8.
The disposition of 200 mg/kg of 14C-labelled sucrose octa-isobutyrate (14C-SOIB), a component of sucrose acetate isobutyrate (SAIB), a beverage emulsion stabilizer, was studied in rats, dogs and monkeys. After oral administration of 14C-SOIB to three rats, 3-15% of the dose was excreted as volatile products, 1-2% appeared in urine and 78-93% was recovered in faeces. In dogs, recoveries of radiolabel in CO2, urine and faeces were approximately 1%, less than 2% and 77-94%, respectively. Monkeys excreted the majority of the dose in faeces; less than 2% of the administered radioactivity was eliminated in either CO2 or urine. The biliary excretion of radiolabel from 14C-SOIB was negligible in rats and monkeys; however, in dogs, 3-10% of the dose was excreted into bile. It was demonstrated by chromatographic analyses of faeces that 14C-SOIB was more extensively hydrolysed in the gastro-intestinal tract of rats and dogs than in monkeys. The results indicate that after oral administration, rats and dogs absorb SOIB following hydrolysis of the sugar ester in the gut. The proportion of the dose that is absorbed by the rat is oxidized to CO2. In the dog, little of the absorbed product is oxidized; rather, it is circulated through an enterohepatic pathway. In contrast, in the monkey, SOIB is not detectably hydrolysed in the gut or absorbed. These findings show that there is a species difference in the disposition of SOIB; the most salient findings relate to a difference in the disposition of SOIB in the dog compared with the rat.
对饮料乳化剂蔗糖乙酸异丁酸酯（SAIB）的一种成分——200mg/kg的14C标记蔗糖八异丁酸酯（14C-SOIB）在大鼠、狗和猴子体内的处置情况进行了研究。给三只大鼠口服14C-SOIB后，3% - 15%的剂量以挥发性产物形式排出，1% - 2%出现在尿液中，78% - 93%在粪便中回收。在狗体内，放射性标记在二氧化碳、尿液和粪便中的回收率分别约为1%、不到2%和77% - 94%。猴子排出的大部分剂量在粪便中；给予的放射性活度不到2%在二氧化碳或尿液中消除。14C-SOIB的放射性标记在大鼠和猴子体内的胆汁排泄可忽略不计；然而，在狗体内，3% - 10%的剂量排泄到胆汁中。通过对粪便的色谱分析表明，14C-SOIB在大鼠和狗的胃肠道中比在猴子中更易广泛水解。结果表明，口服后，大鼠和狗在肠道中糖酯水解后吸收SOIB。大鼠吸收剂量的一部分被氧化为二氧化碳。在狗体内，吸收的产物很少被氧化；相反，它通过肠肝循环途径循环。相比之下，在猴子体内，SOIB在肠道中未检测到水解或吸收。这些发现表明，SOIB的处置存在种属差异；最显著的发现是狗与大鼠相比，SOIB的处置存在差异。
