研究恶性疟原虫感染诱导的红细胞刚性。

Department of Physics, Indian Institute of Science, Bangalore, 560012, India.

Inserm U1016, CNRS UMR8104, Cochin Institute, Paris, 75014, France.

Sci Rep. 2019 Apr 19;9(1):6336. doi: 10.1038/s41598-019-42721-w.

We study the effect of different chemical moieties on the rigidity of red blood cells (RBCs) induced by Plasmodium falciparum infection, and the bystander effect previously found. The infected cells are obtained from a culture of parasite-infected RBCs grown in the laboratory. The rigidity of RBCs is measured by looking at the Brownian fluctuations of individual cells in an optical-tweezers trap. The results point towards increased intracellular cyclic adenosine monophosphate (cAMP) levels as being responsible for the increase in rigidity.

我们研究了不同化学基团对恶性疟原虫感染引起的红细胞刚性的影响，以及之前发现的旁观者效应。受感染的细胞是从实验室培养的寄生虫感染的红细胞培养物中获得的。通过在光学镊子陷阱中观察单个细胞的布朗运动来测量红细胞的刚性。结果表明，细胞内环腺苷酸（cAMP）水平的升高是导致刚性增加的原因。