Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Pediatrics, Hallands Hospital Halmstad, Halmstad, Sweden.
Obesity (Silver Spring). 2019 Jun;27(6):982-988. doi: 10.1002/oby.22453. Epub 2019 Apr 19.
This study aimed to investigate how visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volumes were associated with metabolic risk factors in 7-year-old children.
A total of 81 children (52% girls) from a Swedish birth cohort were studied. At 6 years of age, anthropometric data, fasting insulin, glucose, cholesterol, and blood pressure were collected on 53 children with normal weight and 28 children with overweight or obesity, and insulin resistance was estimated. At 7 years of age, magnetic resonance imaging quantified VAT and SAT. Sex and regression analyses were conducted.
SAT was more strongly associated with metabolic risk factors than VAT. The associations between VAT and metabolic risk factors were stronger in girls (P < 0.05). When VAT was adjusted for birth weight and maternal BMI and education, it accounted for 51% of insulin variance (β = 11.72; P = 0.001) but only in girls. The key finding of this study was that adjusted SAT accounted for 63% of the fasting insulin variance in girls (β = 2.76; P < 0.001). Waist circumference was the best anthropometric marker for insulin resistance.
Insulin resistance was associated with abdominal adipose tissue and its associated metabolic risk factors in children as young as 7 years old.
本研究旨在探讨内脏脂肪组织（VAT）和皮下脂肪组织（SAT）体积与 7 岁儿童代谢危险因素的关系。
对来自瑞典出生队列的 81 名儿童（52%为女孩）进行了研究。在 6 岁时，对 53 名体重正常和 28 名超重或肥胖的儿童进行了体重指数、空腹胰岛素、血糖、胆固醇和血压的采集，并估计了胰岛素抵抗。在 7 岁时，磁共振成像对 VAT 和 SAT 进行了定量分析。进行了性别和回归分析。
SAT 与代谢危险因素的相关性强于 VAT。VAT 与代谢危险因素的相关性在女孩中更强（P<0.05）。当 VAT 按出生体重、母亲 BMI 和教育程度进行调整时，它解释了胰岛素变异的 51%（β=11.72；P=0.001），但仅在女孩中如此。本研究的主要发现是，调整后的 SAT 解释了女孩中 63%的空腹胰岛素变异（β=2.76；P<0.001）。腰围是胰岛素抵抗的最佳人体测量标志物。
在 7 岁的儿童中，胰岛素抵抗与腹部脂肪组织及其相关代谢危险因素有关。
