在体氘标记支持记忆 T 细胞在骨髓中维持的动态模型。
In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow.
机构信息
Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
出版信息
Immunol Lett. 2019 Jun;210:29-32. doi: 10.1016/j.imlet.2019.04.004. Epub 2019 Apr 17.
The maintenance and dynamics of memory T-cells in the bone marrow are a matter of ongoing debate. It has been suggested that memory T-cells in the bone marrow are maintained as long-lived, quiescent cells. We have recently shown that memory T-cells isolated from goat bone marrow undergo self-renewal and recirculate via the blood and lymph. Using the well-established memory T-cell markers CD44 and CD62L we here show very similar results in mice. This provides further support for the concept that memory T-cells are continuously self-renewing and recirculating between blood, bone marrow, spleen and lymph nodes.
骨髓中记忆 T 细胞的维持和动态变化是一个持续争论的问题。有人提出，骨髓中的记忆 T 细胞作为长寿的静止细胞而被维持。我们最近表明，从山羊骨髓中分离的记忆 T 细胞通过血液和淋巴进行自我更新和再循环。使用成熟的记忆 T 细胞标志物 CD44 和 CD62L，我们在此在小鼠中得到了非常相似的结果。这为记忆 T 细胞在血液、骨髓、脾脏和淋巴结之间不断自我更新和再循环的概念提供了进一步的支持。
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