Department of Integrated Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Pulm Pharmacol Ther. 2019 Jun;56:116-125. doi: 10.1016/j.pupt.2019.04.002. Epub 2019 Apr 17.
Chronic obstructive pulmonary disease (COPD) is a common lung disease characterised by progressive, irreversible airflow limitation. Multiple regulatory pathways are involved in COPD pathogenesis. Emerging evidence from clinical and basic medical research has suggested that autophagy-a highly conserved catabolic process mediated under various cellular stress conditions-plays a role in the development and prognosis of COPD. Nevertheless, precise function of autophagy remains debatable owing to its beneficial as well as detrimental consequences. In this review, we summarised the 'double-edged sword' functions of autophagy in COPD and aimed to distinguish and classify these functions on the basis of various factors, such as different airway cell types and autophagy stimulators and modulators. Moreover, we determined the biological-functional consequences of autophagy. In particular, we discussed mitophagy-also termed mitochondrial autophagy-which is a critical process in cellular energy homeostasis. We hope that our findings will shed new light on future therapeutic strategies for COPD.
慢性阻塞性肺疾病（COPD）是一种常见的肺部疾病，其特征为进行性、不可逆转的气流受限。多种调节途径参与 COPD 的发病机制。来自临床和基础医学研究的新证据表明，自噬——一种在各种细胞应激条件下介导的高度保守的分解代谢过程——在 COPD 的发生和预后中发挥作用。然而，由于自噬的有益和有害后果，其确切功能仍存在争议。在这篇综述中，我们总结了自噬在 COPD 中的“双刃剑”功能，并旨在根据不同的因素（如不同的气道细胞类型和自噬刺激物和调节剂）来区分和分类这些功能。此外，我们确定了自噬的生物学功能后果。特别是，我们讨论了线粒体自噬，它是细胞能量稳态的关键过程。我们希望我们的发现将为 COPD 的未来治疗策略提供新的思路。
