Quackery has for centuries used aphrodisiacs to exploit vulnerable victims, 30% of whom, through the power of suggestion, have achieved sexual success from potions, powders and genital pomades. In the 1970s we still have no magical alchemy for sexual joy, but we are for the first time becoming aware of the complexity of human sexual functioning. We realize that new horizons of knowledge regarding cerebral as well as peripheral genital pathways and controls await discovery. Sexual side-effects requiring treatment must not only be noted but carefully and scientifically studied by physicians since these may offer important avenues of understanding of the many unsolved riddles of the neurophysiology of the human sexual response.