Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht, The Netherlands; School for Oncology and Developmental Biology (GROW), Maastricht University, Maastricht, The Netherlands.
Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center+, Maastricht, The Netherlands.
Fertil Steril. 2019 Jun;111(6):1151-1158. doi: 10.1016/j.fertnstert.2019.01.035. Epub 2019 Apr 17.
To evaluate the growth, health, and motor development of children born after preimplantation genetic diagnosis (PGD).
Observational cohort study and comparison of 5-year-old children born after PGD to similar aged children born after IVF/intracytoplasmic sperm injection (ICSI) and children from families with a genetic disorder born after natural conception (NC).
University hospital.
PATIENT(S): One hundred three children were included in the PGD group. The two control groups consisted of 90 children born after IVF/ICSI and 58 children born after NC.
INTERVENTION(S): PGD.
MAIN OUTCOME MEASURE(S): We measured height, weight, body circumferences, body mass index, and blood pressure and performed a dysmorphological and neurological examination. We also collected data about the children's medical history, health care consultations, and motor milestones.
RESULT(S): The mean height, weight, and body mass index were comparable for all groups. Six (5.8%) PGD, four (4.4%) IVF/ICSI, and five (8.6%) NC children had a major congenital abnormality. The incidence of acute and chronic illnesses was similar in all groups. Motor milestones were achieved on time, but the IVF/ICSI group had a slightly younger mean sitting age. None of the children had severe neurological problems.
CONCLUSION(S): Five-year-old children born after PGD show normal growth, health, and motor development when compared with children born after IVF/ICSI and NC children from families with a genetic disorder.
NCT02149485.
评估胚胎植入前遗传学诊断（PGD）后儿童的生长、健康和运动发育情况。
观察性队列研究，比较 5 岁的 PGD 出生儿童与体外受精/胞浆内单精子注射（ICSI）后出生的类似年龄儿童以及自然受孕（NC）后出生的遗传疾病家庭儿童。
大学医院。
共有 103 名儿童纳入 PGD 组。两个对照组包括 90 名接受 IVF/ICSI 治疗后出生的儿童和 58 名接受 NC 治疗后出生的儿童。
PGD。
我们测量了身高、体重、体围、体重指数和血压，并进行了畸形和神经学检查。我们还收集了有关儿童病史、保健咨询和运动里程碑的数据。
所有组的平均身高、体重和体重指数均相似。6 名（5.8%）PGD、4 名（4.4%）IVF/ICSI 和 5 名（8.6%）NC 儿童有重大先天性异常。所有组的急性和慢性疾病发病率相似。运动里程碑按时达到，但 IVF/ICSI 组的平均坐年龄稍小。没有儿童有严重的神经问题。
与 IVF/ICSI 后出生的儿童和遗传疾病家庭的 NC 儿童相比，PGD 后 5 岁的儿童生长、健康和运动发育正常。
NCT02149485。
