Loskutoff D J, Ny T, Sawdey M, Lawrence D
J Cell Biochem. 1986;32(4):273-80. doi: 10.1002/jcb.240320404.
Cultured bovine aortic endothelial cells have a relatively complex fibrinolytic system that is responsive to both the physiological state of the cell itself and to a variety of agents added to the culture medium. The fibrinolytic activity of these cells results from the production of both urokinase-type and tissue-type plasminogen activators and is regulated by an inhibitor capable of neutralizing their activities. The properties of these fibrinolytic components will be reviewed, and their respective roles in initiating and regulating the fibrinolytic activity of the cells will be summarized. A cDNA coding for the inhibitor has been isolated, and its sequence will be compared to that of other serine proteinase inhibitors.
培养的牛主动脉内皮细胞具有相对复杂的纤维蛋白溶解系统，该系统对细胞自身的生理状态以及添加到培养基中的多种因子均有反应。这些细胞的纤维蛋白溶解活性源于尿激酶型和组织型纤溶酶原激活剂的产生，并受一种能够中和其活性的抑制剂调节。本文将综述这些纤维蛋白溶解成分的特性，并总结它们在启动和调节细胞纤维蛋白溶解活性中的各自作用。已分离出编码该抑制剂的cDNA，并将其序列与其他丝氨酸蛋白酶抑制剂的序列进行比较。
