多发性骨髓瘤中的髓外疾病——争议与未来方向。
Extramedullary disease in multiple myeloma - controversies and future directions.
机构信息
Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Department of Hemato-Oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
出版信息
Blood Rev. 2019 Jul;36:32-39. doi: 10.1016/j.blre.2019.04.002. Epub 2019 Apr 13.
Extramedullary disease of multiple myeloma (EM) remains a treatment challenge even in the era of new drugs. While many reports analyzing various aspects of EM have been published, mechanism of EM development has not been clarified yet. This review summarizes current knowledge about this clinical entity, including its history, diagnostics, imaging methods, incidence, prognosis, current treatment options, risk factors and known molecular mechanisms that might be involved in pathogenesis of EM.
多发性骨髓瘤的髓外疾病（EM）即使在新药时代仍然是一个治疗挑战。虽然已经发表了许多分析 EM 各个方面的报告，但 EM 发展的机制尚未阐明。这篇综述总结了目前关于这一临床实体的知识，包括其历史、诊断、影像学方法、发病率、预后、当前治疗选择、危险因素和已知可能参与 EM 发病机制的分子机制。
Zotero 插件