Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Paediatr Respir Rev. 2019 Nov;32:23-27. doi: 10.1016/j.prrv.2019.03.006. Epub 2019 Apr 4.
Aspiration can cause acute symptoms and chronic lung disease in the developing lung. However, the source of aspiration in infants is often unclear, making the choice of intervention difficult.
To quantify the source, amount and duration of lung aspiration in infants using gamma scintigraphy.
Two infants with clinical evidence of gastroesophageal reflux and oropharyngeal dysphagia swallowed formula radiolabeled with technetium on Visit 1. Radiolabeled-formula was instilled by nasogastric tube on Visit 2. Lung aspiration was quantified over four hours and expressed as percent of total radioactivity administered.
Aspiration was greatest with swallowing, compared to instillation, peaking between 2.0% and 2.4% within 30 min and between 0.40% and 0.65% within 20 min, respectively. Radioactivity remained above zero four hours after either administration.
Quantification of the source, amount and duration of lung aspiration in infants is feasible using gamma scintigraphy. The impact of aspiration accrual on clinical care deserves further investigation.
吸入可导致发育中肺的急性症状和慢性肺病。然而，婴儿吸入的来源往往不清楚，这使得干预措施的选择变得困难。
使用伽马闪烁成像术定量评估婴儿肺部吸入的来源、量和持续时间。
两名有胃食管反流和口咽吞咽困难临床证据的婴儿在第 1 次就诊时吞下了锝标记的配方奶。在第 2 次就诊时，通过鼻胃管注入放射性标记的配方奶。在 4 小时内定量评估肺部吸入，并表示为给予的总放射性活度的百分比。
与灌注相比，吞咽时的吸入量最大，在 30 分钟内分别达到 2.0%至 2.4%的峰值，在 20 分钟内达到 0.40%至 0.65%的峰值。两种给药方式后，4 小时内放射性活度仍高于零。
使用伽马闪烁成像术可定量评估婴儿肺部吸入的来源、量和持续时间。吸入累积对临床护理的影响值得进一步研究。
