Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Pharmacy Practice, Massachusetts College of Pharmacy and Health Sciences University School of Pharmacy, Boston, Massachusetts, USA.
Clin Pharmacol Ther. 2019 Oct;106(4):726-733. doi: 10.1002/cpt.1477. Epub 2019 Jul 5.
The HIV type-1 nonnucleoside reverse transcriptase inhibitor, efavirenz, is widely used to treat HIV type-1 infection. Efavirenz is predominantly metabolized into inactive metabolites by cytochrome P450 (CYP)2B6, and patients with certain CYP2B6 genetic variants may be at increased risk for adverse effects, particularly central nervous system toxicity and treatment discontinuation. We summarize the evidence from the literature and provide therapeutic recommendations for efavirenz prescribing based on CYP2B6 genotypes.
HIV-1 非核苷类逆转录酶抑制剂依非韦伦广泛用于治疗 HIV-1 感染。依非韦伦主要通过细胞色素 P450(CYP)2B6 代谢为无活性的代谢物,具有某些 CYP2B6 遗传变异的患者发生不良反应的风险可能增加,尤其是中枢神经系统毒性和治疗中止。我们总结了文献中的证据,并根据 CYP2B6 基因型为依非韦伦的处方提供治疗建议。