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[一项关于2型糖尿病患者睡眠时间与全因死亡率风险的前瞻性队列研究]

[A prospective cohort study on the duration of sleep and risk of all-cause mortality among patients with type 2 diabetes].

作者信息

Chen Y J, Su J, Qin Y, Li Y, Pan E C, Gao Y, Zhang N, Zhou J Y, Yu X J, Wu M, Shen C

机构信息

School of Public Health, Southeast University, Nanjing 210009, China.

Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2019 Apr 10;40(4):394-399. doi: 10.3760/cma.j.issn.0254-6450.2019.04.005.

Abstract

To investigate the relationship between duration of sleep and all-cause mortality in patients with type 2 diabetes. A total of 17 452 type 2 diabetic patients who were under the National Basic Public Health Service Project, in Changshu county, Qinghe district and Huai'an district in Huai'an city of Jiangsu province, were recruited as participants. Cox proportional hazards regression models were used to estimate the associations between different levels on the duration of sleep and all-cause mortality. Stratified analysis was performed according to factors as gender, age, and lifestyle. Among the 67 912 person-years of observation, from the fo1low- up program, the median time of follow-up was 4 years, with 1 057 deaths occurred during the follow-up period. Taking patients with duration of sleep as 7 h/d for reference, the multivariate adjusted hazard ratios (95) of all-cause mortality appeared as ≤6, 8, 9 and ≥10 h/d were 1.14 (0.94-1.37), 1.10 (0.91-1.32), 1.33 (1.05-1.70), and 1.52 (1.24-1.87), respectively which were associated with the duration of sleep. Data from the subgroup analysis showed that this was consistent with the whole population. Longer duration of sleep was associated with the all-cause mortality but no significant association was found between shorter duration of sleep and the all-cause mortality. Longer duration of sleep seemed to have increased the risk of all-cause mortality in type 2 diabetic patients.

摘要

探讨2型糖尿病患者睡眠时间与全因死亡率之间的关系。招募了江苏省淮安市清河区、淮安区以及常熟县参加国家基本公共卫生服务项目的17452例2型糖尿病患者作为研究对象。采用Cox比例风险回归模型评估不同睡眠时间水平与全因死亡率之间的关联,并根据性别、年龄和生活方式等因素进行分层分析。在随访项目的67912人年观察中,随访时间中位数为4年,随访期间有1057例死亡。以睡眠时间为7小时/天的患者作为参照,睡眠时间≤6、8、9和≥10小时/天的全因死亡率多因素调整风险比(95%CI)分别为1.14(0.94-1.37)、1.10(0.91-1.32)、1.33(1.05-1.70)和1.52(1.24-1.87),均与睡眠时间有关。亚组分析数据表明,这与总体人群一致。较长睡眠时间与全因死亡率相关,但较短睡眠时间与全因死亡率之间未发现显著关联。较长睡眠时间似乎增加了2型糖尿病患者全因死亡的风险。

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